Transcriptome profiling of monocytes from XLA patients revealed the innate immune function dysregulation due to the BTK gene expression deficiency. J Immunol (2006) 176:3635–41. In this review, we discuss the role of BTK in B cell differentiation and B cell malignancies and highlight the importance of BTK inhibition in cancer therapy. Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. Lougaris V, Baronio M, Vitali M, Tampella G, Cattalini M, Tassone L, et al. Adv Biol Regul. Wang JD, Chen XY, Ji KW, Tao F. Targeting Btk with ibrutinib inhibit gastric carcinoma cells growth. Nature. Wiczer TE, Levine LB, Brumbaugh J, Coggins J, Zhao Q, Ruppert AS, et al. doi:10.4049/jimmunol.1003631, 56. Melcher M, Unger B, Schmidt U, Rajantie IA, Alitalo K, Ellmeier W. Essential roles for the Tec family kinases Tec and Btk in M-CSF receptor signaling pathways that regulate macrophage survival. "Advances in X-linked immunodeficiency diseases". Jongstra-Bilen J, Puig Cano A, Hasija M, Xiao H, Smith CI, Cybulsky MI. Y223 and Y551 represent two critical tyrosine phosphorylation sites in the SH3 and kinase domain (7). ), Check our recent promotion and sale events, AdScreen™ MAPK Inhibitor Compound Library, AdScreen™ PI3K/Akt/mTOR Inhibitor Compound Library, Btk inhibitor 1 R enantiomer hydrochloride, Simonowski A, .et al.
demonstrated that BTK was critically required for NLRP3 inflammasome-dependent IL-1β release from murine macrophages. Amoras AL, Kanegane H, Miyawaki T, Vilela MM. Preclinical investigation of ibrutinib, a Bruton’s kinase tyrosine (Btk) inhibitor, in suppressing glioma tumorigenesis and stem cell phenotypes. doi:10.1080/2162402X.2015.1057385, 45. The Btk family kinases represent new members of non-receptor tyrosine kinases, which include Btk/Atk, Itk/Emt/Tsk, Bmx/Etk, and Tec. Neutrophil development and function critically depend on Bruton tyrosine kinase in a mouse model of X-linked agammaglobulinemia. Reports by us (10) and others (54) recently identified BTK as a direct regulator in NLRP3 inflammasome activation (Figure 2): Ito et al. Agammaglobulinemia. Sci Rep (2017) 7:6836. doi:10.1038/s41598-017-06342-5, 25.
doi:10.4049/jimmunol.176.6.3635, 14.
On a more global immunoregulatory level, downregulation of innate immune-related genes and an upregulation of oxidative phosphorylation and apoptosis-related genes was observed in XLA patients (24). doi:10.1038/nm.3806, 59. All authors collected and analyzed data, AW coordinated the study and drafted the manuscript, and all authors contributed toward and approved the final manuscript. Chronic apical periodontitis is characterized by alveolar bone absorption in the apical region and is the result of the participation of various inflammatory mediators. PCI-32765 is an orally bioavailable small-molecule inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. BTK inhibitor 1 (compound 27) is an inhibitor of BTK with an IC50 of 0.11 nM for Btk and inhibits B cell activation in hWB with an IC50 of 2 nM.
PLoS One (2017) 12:e0175961. doi:10.1074/jbc.M508892200, 21. Notes: Role of Bruton’s tyrosine kinase downstream of the B cell receptor. Figure 2. J Allergy Clin Immunol (2017) 140:1054–67.e10.