The germinal center founder cell is activated in the extrafollicular compartment (see Fig. The lymphatics drain toward the commissures of the eyelids, with the lateral commissures draining to the parotid lymph nodes and the medial regions draining to the submandibular lymph nodes. 1. The main difference between tonsils and lymph nodes is that tonsils are large masses of lymphoid tissue found in the walls of the pharynx and nasopharynx, and at the base of the tongue, whereas lymph nodes are small masses of confluent lymphoid follicles found along lymphatic vessels. Also, lymph nodes contain T and B lymphocytes, plasma cells, macrophages, and antibodies. Large numbers of cells containing Ig were demonstrated in the follicle centres, γ, μ, δ and α heavy … – Own work (CC BY 3.0) via Commons Wikimedia 2. The main function of lymph nodes is to filter pathogens, antigen-presenting cells, soluble antigens, and a few amounts of B cells from the lymph. Here, macrophages receive the phagocytized pathogens by the epithelial cells. which are secreted locally. Moreover, another difference between tonsils and lymph nodes is that tonsils are large masses of MALT while lymph nodes are small masses of MALT whose diameter is less than 1 mm. These vessels terminate as small radiating superficial conjunctival vessels. You should note that these partially encapsulated Alejo Chorny, Andrea Cerutti, in Mucosal Immunology (Fourth Edition), 2015. Owen and Jones prepared these tissues for light, scanning, and transmission electron microscopy. CD21 is expressed abundantly on both FDCs and B cells and may function by localizing antigen to the FDC network and/or by lowering the threshold of B-cell activation via recruitment of CD19 into the BCR (Tarlinton, 1998). GuineeJr., in Pulmonary Pathology (Second Edition), 2018. Lymphocytes may be present in the adjacent bronchiolar epithelium. The epithelial cells are able to phagocytose bacteria, and transfer them to macrophages, which then present the foreign antigens to B-cells, which are activated (with the help of T cells). Brian C. Quigley, N. Volkan Adsay, in Macsween's Pathology of the Liver (Seventh Edition), 2018, Scattered lymphoid follicles may be present in usual cases of chronic cholecystitis, but when prominent lymphoid follicles number at least three per centimetre (as defined by some studies), in some cases mimicking lymphoma,141 the term follicular cholecystitis may be employed.142–144 Less than 2% of resected gallbladders show this pattern of inflammation, and it is more common in patients in the midseventh decade of life. 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