It may involve taking an antibiotic once a week for 12 weeks or every day for 9 months. Literature in this field was systematically identified on PubMed using the key words “tuberculous meningitis,” “tuberculosis cerebrospinal fluid,” and “tuberculosis nervous system,” as well as combing through the bibliography of relevant papers. Tuberculous meningitis (TBM) is caused by Mycobacterium tuberculosis (M. tuberculosis) and is the most common form of central nervous system (CNS) tuberculosis (TB). Our editors will review what you’ve submitted and determine whether to revise the article. of TB Care in India RNTCP 3. The World Health Organization recommends that anti-TB therapy be started first, followed by ARV treatment within eight weeks [34]. 2nd part of the presentation. DOTS DOTS (directly observed treatment, short-course), is the name given to the World Health Organization-recommended tuberculosis control strategy that combines five components: 1. Comment goes here. Their ability to penetrate the CSF has yet to be adequately studied (Table 2). TB Treatment Regimens for Pregnant Women; Diagnosis: Treatment: Latent TB Infection: 4-month daily regimen of rifampin (RIF) (4R) 3-month daily regimen of isoniazid (INH) and RIF (3HR) 6- or 9-month daily regimen of INH (6H or 9H) , with pyridoxine (vitamin B6) supplementation 1. However, delaying ARV therapy in patients coinfected with HIV and TB has been associated with higher mortality [75]. Since there are no controlled trials comparing corticosteroid regimens, treatment choice should be based on those found to be effective in published trials. Although ELISA assays have been developed to detect antibodies directed against specific mycobacterial antigens in the CSF with varying sensitivities, their limited availability precludes their use as point-of-care tests in resource-poor countries [17, 20]. Multiple studies have shown MDR-TB to be more commonly found in HIV-infected patients with concurrent TBM [78–80], often leading to treatment failure and very high mortality. Doctors prescribe antibiotics to kill the bacteria that cause it. Upcoming SlideShare. Short Couse Chemotherapy It is widely accepted as treatment of choice for TB. While neutralization of TNFα predisposes individuals to TB including TBM [11], TNFα is also considered to play an important role in contributing to the pathogenesis of TBM [60–63], consistent with the aforementioned deleterious effects of the CNS inflammatory response. In patients with TBM, there may be nonosmotic stimuli for antidiuretic hormone (ADH) expression, resulting in a syndrome of inappropriate ADH (SIADH) release. Get the best essay, research papers or dissertations. Most infections show no symptoms, in which case it is known as latent tuberculosis. 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