Neuroblastoma is a heterogeneous malignancy with prognosis ranging from near uniform survival to high risk for fatal demise. Get the latest public health information from CDC: https://www.coronavirus.gov. 2019 Oct 16;19(1):961. doi: 10.1186/s12885-019-6186-z. Neuroblastoma serves as a paradigm for the prognostic utility of biologic and clinical data and the potential to tailor therapy for patient cohorts at low, intermediate, and high risk for recurrence. Rofo. This article summarizes our understanding of neuroblastoma biology and prognostic features and discusses their impact on current and proposed risk stratification schemas, risk-based therapeutic approaches, and the development of novel therapies for patients at high risk for failure. Clipboard, Search History, and several other advanced features are temporarily unavailable. 2010 Feb;24(1):65-86. doi: 10.1016/j.hoc.2009.11.011.  |  Please enable it to take advantage of the complete set of features! Taylor JS, Sha L, Ikegaki N, Zeki J, Deaton R, Harris J, Coburn J, Yavuz B, Sethi A, Shimada H, Kaplan DL, Gann P, Chiu B. J Pediatr Surg. 2020 Jun;167(6):969-977. doi: 10.1016/j.surg.2020.01.012. Neuroblastoma is the most common malignant neoplasm that mostly occurs in neonates. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Different factors can affect the type of neuroblastoma a child has and their prognosis. [Prognosis of neuroblastoma in childhood. Children with high-risk neuroblastoma may receive immunotherapy drugs that stimulate the immune system to kill the neuroblastoma cells. The importance of local control management in high-risk neuroblastoma in South Africa. Children with a high-risk neuroblastoma (most stage 4 neuroblastomas) have a poor prognosis, but low-risk neuroblastomas have a good prognosis … Stage 4 neuroblastoma is a high-risk neuroblastoma. Neuroblastoma in the very young child: biological considerations. NLM  |  7,752,060 and 8,719,052. 2020 Apr;36(4):457-469. doi: 10.1007/s00383-020-04627-x. Neuroblastoma, a neoplasm of the sympathetic nervous system, is the second most common extracranial malignant tumor of childhood and the most common solid tumor of infancy. The prognosis is more guarded for patients with high-risk neuroblastoma, with less than a 50% long-term survival rate. This site needs JavaScript to work properly. Biosci Rep. 2019 Dec 20;39(12):BSR20192050. Neuroblastoma most commonly arises in and around the adrenal glands, which have similar origins to nerve cells and sit atop the kidneys. Neuroblastoma, a neoplasm of the sympathetic nervous system, is the second most common extracranial malignant tumor of childhood and the most common solid tumor of infancy. Epub 2010 Dec 17. Newer treatments. 2019 Dec;54(12):2595-2599. doi: 10.1016/j.jpedsurg.2019.08.022. USA.gov. The treatment uses a radioactive form of the chemical metaiodobenzylguanidine (MIBG). COVID-19 is an emerging, rapidly evolving situation. What Is High-Risk Neuroblastoma or Stage 4 Neuroblastoma? © Copyright 2020 Healthgrades Operating Company, Inc. Patent US Nos. We use cookies to help provide and enhance our service and tailor content and ads. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Neuroblastoma: Biology, Prognosis, and Treatment. Always consult a medical provider for diagnosis and treatment. Neuroblastoma: biological insights into a clinical enigma. Neuroblastoma prognosis depends on many factors, from the child's age to the location and characteristics of the tumor itself. By continuing you agree to the use of cookies. Epub 2020 Feb 28. 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