2018 Dec;2(5):713-725. doi: 10.1042/ETLS20180051.  |  doi: 10.1152/ajprenal.00041.2005. Biophys J. The potential of 4-chloro-ortho-toluidine (4-CloT), an aromatic amine substituted on the ortho- and para-position of the amine function, to induce DNA damage in male Wistar rats was evaluated with the micronucleus test (peripheral blood), Pig-a (peripheral blood), and comet assay (peripheral blood, liver, urinary bladder, jejunum) at several time points. DNA breaks persist as long as NaCl stays high and are rapidly repaired when NaCl is lowered. Epub 2018 Sep 14. Furthermore, those breaks did not induce the DNA repair protein gammaH2AX or cause activation of the MRN (Mre11, Rad50, Nbs1) complex. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/.

Epub 2017 Oct 11.
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Micronucleus assays in rodent tissues other than bone marrow. Dmitrieva NI, Cui K, Kitchaev DA, Zhao K, Burg MB. The purpose of the present studies was to resolve the disparity. Clipboard, Search History, and several other advanced features are temporarily unavailable. Importantly, in both cell types, raising NaCl further to cause apoptosis activates these DNA damage response proteins and greatly fragments DNA, associated with cell death. Time course of appearance of DNA breaks and phosphorylation of H2AX in HeLa cells exposed to survivable (400 mosmol/kgH, Elevation of osmolality to 600 mosmol/kgH, DNA breaks and induction of γH2AX in mIMCD3 cells exposed to high NaCl, elevated to either a survivable (500 mosmol/kgH. Wada K, Katoh Y, Ohnuma-Koyama A, Takahashi N, Yamada M, Matsumoto K. Mutat Res Genet Toxicol Environ Mutagen. Osmotic challenge drives rapid and reversible chromatin condensation in chondrocytes. Mutagenesis. The response to DNA damage is critical for cellular homeostasis, tumor suppression, immunity, and gametogenesis. Get the latest research from NIH: https://www.nih.gov/coronavirus. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error.

Zhang Z, Dmitrieva NI, Park JH, Levine RL, Burg MB. 2011 Jan;26(1):223-30. doi: 10.1093/mutage/geq066. HeLa cells were exposed to high NaCl for 4 h and then immunostained for γH2AX. Activation of caspases in apoptotic HeLa cells (analysis by laser scanning cytometry; LSC). Genes involved in DNA damage responses and 2. Epub 2011 Nov 21. Drugs/Chemicals that cause DNA damage. Clipboard, Search History, and several other advanced features are temporarily unavailable. Chávez-Galán L, Vesin D, Martinvalet D, Garcia I. J Immunol Res. DNA damage and osmotic regulation in the kidney.
Vous pouvez modifier vos choix à tout moment dans vos paramètres de vie privée. 2019 Apr 4;4(4):6245-6256. doi: 10.1021/acsomega.9b00349. NCI CPTC Antibody Characterization Program. Su J, Liu X, Xu C, Lu X, Wang F, Fang H, Lu A, Qiu Q, Li C, Yang T. Am J Physiol Cell Physiol. doi: 10.1152/ajprenal.90424.2008.  | 

The DNA damage response (DDR) is a complex signal transduction pathway which recognizes when DNA is damaged and initiates the cellular response to the damage.

Epub 2018 Dec 21. In contrast to CA and MN assays, the level of initial DNA damage can be analyzed by comet assay directly after treatment before main initiation of DNA …


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