Epub 2020 May 20. The CD40LG gene provides instructions for making a protein called CD40 ligand, which is found on the surface of immune system cells known as T cells. Somatic mutations in human Ig variable genes correlate with a partially functional CD40-ligand in the X-linked hyper-IgM syndrome. Search aliases for CD40LG gene in PubMed and other databases, Request up-to-date GeneHancer data (full dataset), See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB, Immunotag™ CD40LG Antibody (ITA7685-100u), Immunotag™ CD40LG Antibody (ITA6182-100u), CD40L Antibody / TRAP / CD154 (Protein Microarray-Validated Monoclonal), Anti-CD40LG monoclonal antibody, clone S2/70, Anti-Human CD40 ligand Therapeutic Antibody (toralizumab), Anti-Human CD40LG Therapeutic Antibody (dapirolizumab pegol), Anti-Human CD40L Therapeutic Antibody (Antova), Anti-Human CD40LG Therapeutic Antibody scFv Fragment (IDEC131/E6040), Anti-Human CD40LG Therapeutic Antibody Fab Fragment (DOM-31), Anti-Human CD40LG Therapeutic Antibody (DOM-27), Anti-Human CD40LG Therapeutic Antibody (DOM-2), Anti-Human CD40LG Therapeutic Antibody Fab Fragment (DOM-5), Anti-Human CD40LG Therapeutic Antibody scFv Fragment (DOM-20), Mouse Anti-CD40LG Recombinant Antibody (CBXC-0219), Mouse Anti-CD40LG Recombinant Antibody (11J26), Hi-Affi™ Recombinant Rabbit Anti-CD40LG Monoclonal Antibody (DS562AB), Mouse Anti-CD40LG Recombinant Antibody (CBFYC-1302), Mouse Anti-CD40LG Recombinant Antibody (CBXC-2266), Hamster Anti-CD40LG Recombinant Antibody (CBYY-C0158), Recombinant Humanized Anti-CD40LG Antibody Fab Fragment (h24–31), Recombinant Human Anti-CD40L Antibody (BMS2h-100), Human Anti-CD154 Antibody Fab Fragment (CDP7657), Recombinant Humanized Anti-CD154 Antibody (C4LB150), Rat Anti-CD40LG Antibody scFv Fragment (342), Recombinant Mouse Anti-CD40L Antibody (JB5), Humanized Anti-CD154 Antibody Fab Fragment (C4LB150), Humanized Anti-CD154 Antibody scFv Fragment (C4LB150), Afuco™ Anti-CD40LG ADCC Theraputic Antibody (Ruplizumab), ADCC Enhanced, Afuco™ Anti-CD40LG ADCC Theraputic Antibody (Toralizumab), ADCC Enhanced, Recombinant Human Anti-CD40LG Antibody scFv Fragment (C4LB83), Mouse CD40 Ligand/TNFSF5 Antibody (AF1163), Show 476 available IgM Antibodies ranked by validation data, ProteoGenix Custom Antibody Production Services (Monoclonal/ Polyclonal/ Phage display/Ascites & CS), ProteoGenix Custom Monoclonal Antibody Humanization Services (Drug discovery services, Stable cell line, ADCC), Human CD40 Ligand/TNFSF5/CD40L/CD154/T-cell antigen Gp39/gp39, Lyophilized (BAN1452), Human CD40L/TNFSF5/CD40 Ligand/T-Cell Antigen Gp39/TNF-Related Activation Protein/TRAP/Tumor Necrosis Factor Ligand Superfamily Member 5/CD154/CD40LG/TRAP, Lyophilized, Human CD40 Ligand/TNFSF5/CD40L/CD154/T-cell antigen Gp39/gp39, Lyophilized (BAN0109), Recombinant Human CD40L (TNFSF5) (carrier-free) (591704), Recombinant Human CD40L (TNFSF5) (carrier-free) (591702), Recombinant Human CD40L (TNFSF5) (carrier-free) (591708), Recombinant Human CD40L (TNFSF5) (carrier-free) (591706), Recombinant Human CD40L (TNFSF5) (Animal-Free), Recombinant Human CD40 Ligand/TNFSF5 (HEK293-expressed) (6420-CL), Origene Custom Protein Services for CD40LG, Show 131 available IgM Proteins ranked by validation data, ProteoGenix Custom Recombinant Protein Production Services (E.coli/ Mammalian Cells/High throughput Screening), ProteoGenix Custom Peptide Synthesis Service / Conjugation and Modification service, Immunotag™ Human CD40L (Cluster of Differentiation 40 Ligand) ELISA, CD40L Mouse ELISA Kit (with color giving dyes), LEGENDplex(TM) Human CD40L Capture Beads B9, 13X, LEGENDplex(TM) Human sCD40L Capture Bead A8, 13X, LEGENDplex(TM) Human sCD40L Capture Bead B2, 13X, Human CD40 Ligand/TNFSF5 Quantikine ELISA Kit (DCDL40), Human CD40 Ligand/TNFSF5 XL Magnetic Luminex Performance Assay (LUXLM617), Show 112 available IgM Elisa Kits ranked by validation data, Increased vaccinia virus (VACV) infection, Dynamic nuclei (hole, folded or small irregular), Increased endosome-nucleus distance (endosomes dispersed in the cell periphery), Strongly decreased CFP-tsO45G cell surface transport, Synthetic lethal with MLN4924 (a NAE inhibitor), Increased viability with MLN4924 (a NAE inhibitor), Generate A Custom CRISPR Mouse Model For Your Study, CRISPR Clones for CD40LG - Select products 50% OFF >, VectorBuilder CRISPR vectors for CD40LG (ie.
What is a gene mutation and how do mutations occur? Lister Hill National Center for Biomedical. CD40 ligand attaches like a key in a lock to its receptor protein, CD40, which is located on the surface of immune system cells known as B cells. (and/or Entrez Gene and/or Ensembl if different), Santa Cruz Biotechnology (SCBT) Antibodies for CD40LG, Santa Cruz Biotechnology (SCBT) CRISPR for CD40LG. USA.gov. 2003 Oct;56(5):256-62.
CIViC Summary , How are genetic conditions and genes named? The Experimentally Obtained Functional Impact Assessments of 5' Splice Site GT'GC Variants Differ Markedly from Those Predicted. chrX:136648177-136660390 CD40L gene polymorphism was found to be associated with severe falciparum malaria in Indian population especially in severe malarial anaemia. CD40 ligand mutations in x-linked immunodeficiency with hyper-IgM. Online ahead of print. Available from Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). 2001;24(3):311-24. Review. COVID-19 is an emerging, rapidly evolving situation. CD40:CD40L interactions in X-linked and non-X-linked Thusberg J, Vihinen M. The structural basis of hyper IgM deficiency - CD40L