Gynecol Oncol. Meta-Analysis of the Association Between FAS Ligand and TRAIL Genetic Polymorphisms and Intervertebral Disc Degeneration Susceptibility in Chinese Han population. Lupulone (40 microg/ml) up-regulated expression of TRAIL DR4/DR5 death receptors at the cell surface of both c … 2009 Nov 18;285(1):1-5. doi: 10.1016/j.canlet.2009.02.029. Spine (Phila Pa 1976). Isolated disk cells were analyzed by flow cytometry for Fas, FasL, TRAIL, DR4 and DR5 expression. There are three kinds of vectors for choice, cloning …  |  Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Lupulone triggers p38 MAPK-controlled activation of p53 and of the TRAIL receptor apoptotic pathway in human colon cancer-derived metastatic cells. 2018 Oct;41(5):1852-1863. doi: 10.1007/s10753-018-0828-1. [8], TNFRSF10A has been shown to interact with DAP3. This site needs JavaScript to work properly. Epub 2016 Sep 28.



The O-GlcNAcylation-defective DR4 failed to form DISC/necrosome and could not translocate to aggregated platforms for receptor clustering. Association between TRAIL gene polymorphisms and the susceptibility and severity of lumbar disc degeneration.
HHS Skip to Content Our findings demonstrate that DR4 O-GlcNAcylation is crucial for TRAIL death signaling, providing new opportunities for TRAIL therapy overcoming TRAIL resistance in cancers. Fakiruddin KS, Lim MN, Nordin N, Rosli R, Zakaria Z, Abdullah S. Cancers (Basel).

Since TRAIL must specifically bind DR4/5 to initiate apoptosis, the expression of DR4/5 was first examined after the cells were treated with levamisole. [9], tumor necrosis factor-activated receptor activity, activation of NF-kappaB-inducing kinase activity, TRAIL-activated apoptotic signaling pathway, regulation of extrinsic apoptotic signaling pathway via death domain receptors, activation of cysteine-type endopeptidase activity involved in apoptotic process, extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, tumor necrosis factor-mediated signaling pathway, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, GRCh38: Ensembl release 89: ENSG00000104689, GRCm38: Ensembl release 89: ENSMUSG00000022074, "TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL", "Entrez Gene: TNFRSF10A tumor necrosis factor receptor superfamily, member 10a", "FADD is required for DR4- and DR5-mediated apoptosis: lack of trail-induced apoptosis in FADD-deficient mouse embryonic fibroblasts", "Following a TRAIL: update on a ligand and its five receptors", "HLA-DR polymorphism affects the interaction with CD4", "Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL", "Characterization of two receptors for TRAIL", "TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB", "c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB", "Increased expression of death receptors 4 and 5 synergizes the apoptosis response to combined treatment with etoposide and TRAIL", "CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells", "Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain", "Evidence that the human death receptor 4 is regulated by activator protein 1", "Mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in activated T cells abrogates TRAIL-induced apoptosis upstream of the mitochondrial amplification loop and caspase-8", list of human clusters of differentiation, Methoxy polyethylene glycol-epoetin beta (CERA/Mircera), Granulocyte macrophage colony-stimulating factor, Interferon alpha (interferon alfa, IFN-α), FMS-like tyrosine kinase 3 ligand (FLT3L), Leukemia/leukocyte inhibitory factor (LIF), Signaling peptide/protein receptor modulators, https://en.wikipedia.org/w/index.php?title=Death_receptor_4&oldid=978002809, Creative Commons Attribution-ShareAlike License, This page was last edited on 12 September 2020, at 08:16. However, since not all pancreatic cancer cells respond to TRAIL, further improvements and optimizations are still needed. Epub 2006 Dec 15.

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