The PCNA interactions with different cellular proteins and the importance of these interactions are also discussed.
{ECO:0000269 PubMed:24911150}. FATHMM website. Patient Education Our patient education tools and handouts are an important way to influence your patients’ health. For more detailed information about copy number data and gain/loss definitions click here. transcription factors regulating expression of PCNA gene predicted using known transcription factor binding site motifs from the TRANSFAC Predicted Transcription Factor Targets dataset. Users with questions about a personal health condition should consult with a qualified healthcare professional. help pages. cell types and tissues with high or low expression of PCNA protein relative to other cell types and tissues from the ProteomicsDB Cell Type and Tissue Protein Expression Profiles dataset.
The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. phenotypes of transgenic mice caused by PCNA gene mutations from the MPO Gene-Phenotype Associations dataset. This toroidal-shaped protein encircles DNA and can slide bidirectionally along the duplex. The table currently shows only high value (numeric) copy number data. [provided by RefSeq, Jul 2008]. Role of PCNA-dependent stimulation of 3'-phosphodiesterase and 3'-5' exonuclease activities of human Ape2 in repair of oxidative DNA damage. Cullen AE, Centner AM, Deitado R, Salazar JFA. 3. help pages. phenotypes associated with PCNA gene from the curated ClinVar Gene-Phenotype Associations dataset. This identifier remains the same between different assemblies (GRCh37 and GRCh38). Two transcript variants encoding the same protein have been found for this gene. Description: The PCNA gene is situated on human chromosome 20 and it spans about 12 kb. microRNAs regulating expression of PCNA gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. OMIM: ATAXIA-TELANGIECTASIA-LIKE DISORDER, Atlas of Genetics and Cytogenetics in Oncology and, Constitutional mismatch repair deficiency syndrome, GeneEd resources available on Genetics Home Reference, Genetics Home Reference results available from MedlinePlus Connect. Directly interacts with POLD1, POLD3 and POLD4 subunits of the DNA polymerase delta complex, POLD3 being the major interacting partner; the interaction with POLD3 is inhibited by CDKN1A/p21(CIP1) (PubMed:11595739, PubMed:16510448, PubMed:22148433, PubMed:24939902). This section shows publications associated with PCNA.
Rembe JD, Boehm JK, Fromm-Dornieden C, Hauer N, Stuermer EK. To include these
Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. This page contains the complete Methylation data for the gene and filter Interacts (when polyubiquitinated) with ZRANB3 (PubMed:22704558, PubMed:22705370, PubMed:22759634). cell lines with high or low expression of PCNA gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. High (Hypermethylation); Beta-Value > 0.8 and differs from normal average by > 0.5, Low (Hypomethylated); Beta-Value < 0.2 and differs from normal average by > 0.5. The harmonizome: a collection of processed datasets gathered to serve and mine knowledge One of the well-established functions for PCNA is its role as the processivity factor for DNA polymerase delta and epsilon.
193–210. and phenotypic consequences of protein missense variants using hidden Use the range slider to set the general start and end coordinates for doi:10.1007/978-1-4615-5371-7_15. Copy number segments are excluded if the total copy number and minor allele values are unknown. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. The PCNA interactions with different cellular proteins and the importance of these interactions are also discussed. Involved in response to activity and response to bacterium. phenotypes associated with PCNA gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. cellular components co-occuring with PCNA protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. You can see more information in out interacting viral proteins for PCNA from the Virus MINT Protein-Viral Protein Interactions dataset. been screened for mutations. eCollection 2020. Interacts with ANKRD17 (PubMed:23711367). PubMedIDs of publications reporting gene signatures containing PCNA from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. biological terms co-occuring with PCNA gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |